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A major mechanism linking GSH to signal regulation is S-glutathionylation (SSG), a reversible post-translational modification in which GSH forms a mixed disulfide bond with reactive cysteine residues on target proteins

[DOI] [PMC free article] [PubMed] [Google Scholar] 69.De Angelis, M., Anichini, G., Palamara, A

[5] Through gene regulation, estradiol promotes vaginal epithelial maturation, supports collagen synthesis within skin, and contributes to nitric-oxide-mediated vasodilation, collectively providing mechanistic explanations for clinical benefits such as improved vulvovaginal comfort and reduction in hot-flash frequency

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Impaired balance and coordination is a neurological symptom that can be caused by B12 deficiency

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