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GLP-1 receptors are expressed in brain regions involved in reward processing and food motivation, including the nucleus accumbens and ventral tegmental area
At higher doses: Some participants experienced dysesthesia , an abnormal skin sensation Discontinuation rates were higher than placebo A portion of discontinuations were attributed to excessive weight loss , underscoring the importance of careful dosing and clinical oversight Additional late-stage trials are ongoing and will further clarify safety, tolerability, and optimal dosing strategies
doi: 10.1038/nm1168 65 ElsonAETDotsonCDEganJMMungerSD
Hernandez NS, Schmidt HD
Holst, Smidt Gasberg, Rosenkilde
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