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For example, P rats are derived from outbred Wistar rats, whereas the HAD line is derived from N/Nih rats (Li et al., 1979, 1993)

1 If approved, an effective once-daily oral GLP-1 could significantly expand access by lowering delivery barriers, improving adherence for injection-averse patients, and alleviating distribution constraints often associated with injectable formulations

This eases the digestive load and can reduce gastrointestinal symptoms

Serious side effects like pancreatitis or gallbladder disease remain rare (less than 1% of users)

Rev Cardiovasc Med 21(4):531540