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When you can simultaneously suppress appetite via GLP-1 and GIP, improve insulin sensitivity, and turn the metabolic furnace up via glucagon, the body composition consequences start to look qualitatively different from what monotherapy can produce

Westhoff CL, Nelson IS, Suarez-Rodriguez A, Gold MA

Nevertheless, United States Pharmacopeia

MMWR Surveill Summ (2014) 63:121

Genetic factors, baseline body composition, adherence to lifestyle modifications, and duration of treatment all influence outcomes

MOD-GRF (1-29) is a modified fragment of growth hormone-releasing hormone commonly used in research to stimulate pituitary GH release