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Retatrutide is administered subcutaneously, typically in the abdomen, thigh, or upper arm
This is especially important for patients on higher doses who have been on therapy for extended periods
Appetite suppression creates a significant caloric deficit
Because the satiety-signaling mechanism is highly dose-dependent at the upper end of the titration schedule, Wegovy users should especially prioritize the abdomen as their default site to ensure they are getting the full benefit of their prescribed dose
The triple-receptor mechanism produces significant gastrointestinal effects, particularly nausea, when doses increase too quickly
But occasionally something looks wrong
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