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Moreover, even if the bias profile is preserved, tissuespecific manifestations of biased signalling are clearly dependent on how upstream pathway activation is coupled to downstream responses

doi: 10.1038/s41467-021-23111-1 113 GuerreiroR.WojtasA.BrasJ.CarrasquilloM.RogaevaE.MajounieE.et al

"It's important if somebody does start experiencing some new symptoms of any kind on these medications, we have to remember we don't have very long-term data on these meds, so there are still a lot of unknown risks with these medications," Parrella said