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Conversely, there is no evidence for accumulation of valproyl-CoA in brain tissue, suggesting that the effects of VPA in the CNS are independent of the formation of this metabolite [80]

However, conventional oral B12 supplements, such as cyanocobalamin and methylcobalamin, face significant challenges during their transit through the GI tract (23)

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It has also been linked to acute liver injury in rare cases [11]

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R -enantiomer) 59 , which are both highly reactive, labile molecules having covalent bond structures with three consecutive sulfur atoms (see Figure 1a for chemical structures)