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For many women, skin changes become more noticeable during perimenopause and menopause as antioxidant defenses decline alongside estrogen

These occur alongside shared neurodegenerative processes such as mitochondrial dysfunction, oxidative stress, and neuroinflammation

Genistein administration induced Nrf2 enhancement by activation/phosphorylation of keap1, sirt1, MAPK-ERK1/2, PKC, and estrogen receptor in other cells or tissues, such as: hippocampal tissue, hypothalamic paraventricular nucleus, ovary, and Caco-2 cells [131, 135,136,137]

TP53 can enhance ferroptosis by repressing the expression of solute carrier family 7 member 11 or by enhancing the expression of spermidine/spermine N1 acetyltransferase 1 and glutaminase 2 [12]

These sources contain higher concentrations of beneficial compounds compared to conventional options

Pickart, L., Vasquez-Soltero, J.M., and Margolina, A