PMID 18366757
Mechanistically, metformin may activate Nrf2 through multiple pathways, including AMPK activation, inhibition of GSK-3mediated Nrf2 degradation, and modulation of intracellular redox homeostasis, all of which facilitate Nrf2 nuclear translocation and subsequent induction of downstream antioxidant genes 48,49
Wang XX, Myakala K, Libby AB, Krawczyk E, Panov J, Jones BA, et al
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A healthy microbiome is linked to better incretin hormone response, and GLP-1 is an incretin hormone
