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The glycosyltransferase B3GNT3 facilitates the glycosylation of SLC3A2, leading to the stabilization of the SLC3A2 protein and increased interaction between SLC3A2 and SLC7A11 [26]

Furthermore, caffeic acid and zinc effectively reduce diabetes-induced oxidative stress, thereby protecting spermatogenesis [344, 345]

These features are essential for oxygen transport, since RBCs have to undergo repeated shape changes without fragmentation, to assure their passage and oxygen perfusion through all vascular networks, namely, through capillary blood vessels with smaller lumen diameter than that of RBCs [6, 7]