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Retatrutide is currently an investigational compound
However, the study included a small number of participants and a shorter follow up time of only 48 weeks compared to other RCTs studying GLP-1 agonists
All licensed GLP-1 medicationssuch as semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda)are administered via subcutaneous injection or, in limited cases, as oral tablets
These CD8 + T cells attract HSCs with high expression of CCR5 and lead them to apoptosis via the FasL-Fas pathway, which results in the resolution of liver fibrosis (Koda et al., 2021)
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