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In research exploring atherosclerosis, a radiolabeled monoclonal antibody F(ab') 2 fragment directed against the Vdomain of RAGE was developed

In addition, over 99% of the total glutathione produced under these conditions was in the biologically active, reduced form (GSH)

These data demonstrate that metformin alters metabolism, specifically inhibiting oxidative phosphorylation, and induces significant mitochondrial dysfunction in both HCT116 and SW837 cells, supporting its metabolic modulatory effects in CRC in vitro

doi: 10.1016/j.molmed.2023.05.007