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These include anti-inflammatory effects within the trigeminal pain system, reduction of intracranial pressure through decreased CSF [cerebrospinal fluid] secretion, and modulation of CGRP [calcitonin gene-related peptide] (a key migraine-promoting signaling molecule), Yuan said

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Profound nausea at higher doses can cause patients to significantly under-eat, putting them at risk for nutritional deficiencies, dehydration, and lean muscle loss

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Additionally, it reduced HOMA-IR in individuals with diabetes, those without diabetes, and merely diabetic patients for HbA1c and insulin

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