Inhibit osteoclast activation and differentiation, reduce bone resorption Block osteoclast differentiation signal RANKL/RANK/OPG pathway: AOD 9604 downregulates the expression of RANKL (a key factor in osteoclast differentiation) and upregulates the expression of OPG (a RANKL antagonist), reducing the RANKL/OPG ratio by 50-60% and blocking the differentiation of osteoclast precursors into mature osteoclasts
Allergic reactions to cyanocobalamin have been reported and require immediate medical attention
Although a few studies have been conducted in humans, the results are mixed and ultimately the drug is not approved by the US Food and Drug Administration (FDA)
To ensure adequate vitamin B12 intake, it's important to include foods rich in this nutrient in the diet
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While B12 has very low toxicity as a water-soluble vitamin with excess typically excreted in urine, rare adverse reactions can occur