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Semin Thorac Cardiovasc Surg 32(2):337-343, 2020

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Prior to the initiation of valproic acid therapy, evaluation for UCD should be considered in the following patients: 1) those with a history of unexplained encephalopathy or coma, encephalopathy associated with a protein load, pregnancy-related or postpartum encephalopathy, unexplained mental retardation, or history of elevated plasma ammonia or glutamine

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Glutathione peroxidase 4 (GPX4) is an important antioxidant enzyme, when its activity diminishes, results in lipid peroxide accumulation and initiates ferroptosis (You Z