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This effect was associated with upregulation of hydroxyindole-O-methyltransferase (HIOMT), a key enzyme in melatonin biosynthesis (Khavinson & Anisimov, Neuroendocrinology Letters, 2000)

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In the UK, these are primarily regulated as food supplements rather than licensed medicines

2008 Dec;18(6):567-84

Mayo Clinic recommends performing strength training exercises for all major muscle groups two or three times per week. Keep the sessions short enough to repeat consistently

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