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The increase in the activity of antioxidant enzymes, both in the frontal cortex and in the hippocampus, indicates that oxidative stress takes place in neurons and the cellular defense reaction
Potentially, yes
High cortisol levels can also impact other compounds leading to a reduction in immune and inflammatory response as well as cognitive dysfunction (Chen 2015)
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However, in the post-surgical context, distinguishing between medication side effects and surgical complications can be challenging