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Multiple compounds that were thought to be antagonists at D 2 -like receptors (including the antipsychotic drugs haloperidol, chlorpromazine, and clozapine) have been demonstrated to possess inverse agonist activity at D 2 and D 3 receptors

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Studies show that most patients regain a significant portion of lost weight within months of stopping treatment as appetite returns to pre-treatment levels and metabolic signaling reverts

Both are being discussed and in some cases sold online, raising serious patient safety concerns