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In addition, GSH depletion induced SIPS, as evidenced by increased percentage of the senescence-associated -galactosidase-positive cells, increased senescence-associated heterochromatin foci (SAHF), as well as cell cycle arrest at the G1 phase

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Control mice showed significant hepatic steatosis after 1 week of MCDD feeding, whereas mice with GSTM2 overexpression showed this effect at 4 weeks

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Ann Rev Physiol