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While the pain may start as a dull ache, it can quickly progress into sharp, persistent discomfort if not treated properly

For comparisons between two specific groups, the MannWhitney U test was applied

doi: 10.3390/ijms21093289 55

Unlike sepsis, where treatments are primarily directed against LPS-induced inflammatory responses (e.g., anti-endotoxin antibodies), SAP-induced glycocalyx damage is predominantly driven by pancreatic enzyme activation (e.g., trypsin) and intestinal endotoxin release