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Therefore, this review elucidates the etiology, inducements, pathogenesis and treatment modalities of migraine, the clinical evidence that migraine is associated with oxidative stress and neurogenic inflammation, as well as the experimental evidence of antioxidant and anti-inflammatory effects of topiramate, which is of great significance for further research and exploration of the possible mechanisms of topiramate in the treatment of migraine by modulating oxidative stress and neurogenic inflammatory pathways

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60,61 Overview of ferroptosis Ferroptosis is a cellular response to oxidative stress that depends on excess iron, phospholipids (PLs) with polyunsaturated fatty acid chains (PUFAs), and ROS