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this, in turn, resulted in the upregulated expression of telomere repeat-binding factor 1/2 (TRF1/TRF2) proteins and strict dependence on p53/p21 signaling, followed by irreversible G2/M cell cycle arrest, ultimately leading to apoptosis

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Cystine transported by SLC7A11 induces the response of actin cytoskeleton proteins to disulfide stress, leading to disulfide-induced apoptosis [107]

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