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This condition, mainly caused by bacterial infections, oxidative stress, alcohol or chronic allergen exposure, and dysbiosis, leads to the development of several pathologic conditions, including obesity, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), liver cirrhosis, neurodegeneration, cardiovascular diseases, inflammatory bowel disease, celiac disease, irritable bowel syndrome, type 1 diabetes mellitus (T1D), and several autoimmune conditions (Fig

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Therefore, p53-mediated ferroptosis in tubular epithelial cell may be a therapeutic target for alleviating AKI

Humans express two VMAT encoding genes, SLC18A1 which encodes VMAT1 and SLC18A2 which encodes VMAT2