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Canagliflozin inhibits interleukin-1-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms

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The longer exposure window in TRIUMPH-4 (68 weeks vs 24 weeks) is the main explanation for the larger absolute loss, consistent with what has been seen across the class

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Together, these pathways produce greater weight loss, better glucose control, and improved metabolic markers compared to targeting either receptor individually

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