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First isolated from cerebral venous blood in 1977, it gets its name from early research showing it could promote delta-wave sleep the deepest, most restorative stage of sleep associated with physical recovery and growth hormone release

[13] Though the chemistry of ACD is still to be resolved, it shows that isopeptide bond formation is not dependent simply on Asp/Asn for non-terminal isopeptide linkages between proteins

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It is a close structural analogue of the naturallyoccurring GHK-Cu (Copper Tripeptide1), differing only in a single Nterminal residue: alanine in place of glycine (one methyl group)

Eur J Pediatr 2008