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Appetite suppression: GLP-1 works by mimicking the effects of GLP-1, a hormone that is naturally produced in the body and helps to regulate appetite

Pediatr Neurol 36(3):152158

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Likewise, the pars compacta hosts exceptionally large neurons, which require exceptionally large amounts of energy, and these neurons mitochondria may therefore also be particularly vulnerable to dysfunction (Pacelli et al., 2015