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[6] Set that beside the 24 minute half-life and the mismatch is stark: a compound essentially cleared from plasma within 20 minutes, reported to begin acting at 60 minutes and to persist for up to 20 hours

The gel significantly improved skin permeation, achieving a permeability rate of 61.12 1.89% in ex-vivo studies after 24 h substantially higher than the 8.56 2.5% permeability of commercial clobetasol cream