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Its receptor selectivity minimizes stimulation of prolactin, cortisol, or ACTH pathways

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For example, a methylene-linked oxetane increased potency 100-fold relative to the methyl substituent of 5 , leading to the identification of PF-06882961, which is a full agonist (EC 50 = 13 nM) in the CS cAMP assay (Fig

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The candidates selected are predicted to be orally bioavailable according to the analysis of Lipinski et al