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However, tumor cells can remodel TME by several means, including increased immunosuppressive population, reduced infiltration of tumor-inhibitory immune cells, reduced presentation of tumor antigens on MHC molecules, and more, allowing them to evade the immune system ( Figure 3F )
The clinical evidence is more advanced than BPC-157s but still limited and, crucially, mostly concerns the full-length synthetic protein under pharmaceutical development names (RGN-259 for ophthalmic use, RGN-137 for dermal use) rather than the TB-500 fragment sold in research blends
Ann N Y Acad Sci (2011) 1221(1):107
Z.WuW.ZhuQ.LiuX
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