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Landmark trials have established GLP-1 RAs efficacy in reducing major adverse cardiovascular events (MACE) in patients with T2DM and atherosclerotic cardiovascular disease (ASCVD)

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Acknowledgements The authors thank Michael Bonar, Creative Director at the Leicester Diabetes Centre, for the original figure concept

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Other inhibitors have faced challenges, such as poor specificity or high toxicity, which prevent their progression to clinical trials