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This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

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While a weight loss not exceeding 40% of the total body weight loss is considered healthy, semaglutide-induced decline in lean and skeletal mass may occur, raising concerns for notable reductions in lean mass, especially in trials with a larger number of patients [163]

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