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For years, patients using GLP-1 obesity medications have faced a common trade off: strong weight loss but frequent nausea and gastrointestinal side effects

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For patients using newer and more effective incretin mimetics (e.g., ozempic), the weight regain after stopping medication for one year was 9.9kg (from a loss of 14.7kg)

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This was the first case report of its kind when published in 2023, and a second case was subsequently reported in Clinical Kidney Journal in 2025, involving a 36-year-old male following a rapid dose escalation