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A 2025 systematic review and meta-analysis of 12 studies (6,645 participants) confirmed significant correlations between klotho levels and cognitive function, supporting its potential as both biomarker and therapeutic target

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Its effects tend to diminish after 46 weeks of daily use, so strategic breaks are essential to reset the bodys responsiveness and restore its full effectiveness

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Certain antihistamines, decongestants, and even some trace dietary compounds can cause false amphetamine positives because they share the phenethylamine backbone structure with amphetamine itself