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3.2.2.1 Basic science research In animal models of PD, GIP analogs showed promising results with improvement in motor symptoms and reduction of the inflammation response (Li et al., 2016)

As an example of such a multipronged approach, the Neotone formulation simultaneously targeting melanocytes, fibroblasts, and endothelial cells with the combination of five actives (niacinamide, licorice extract, diacetylboldine, a DKK1 agonist, and an inhibitor of EDN-1 synthesis) was found to be as effective as hydroquinone 4% cream in the management of facial melasma, while inducing fewer side effects [214]

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Regulation of the Keap1Nrf2 pathway by p62/SQSTM1

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