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It has been observed that enzymatic inactivation of cisplatin by GSTP1-1 contributes significantly to drug-resistance 77

15 Collectively, these events lead to a vicious cycle of persistent inflammation and chronic oxidative stress, which results in protease-anti-protease imbalance, defects in tissue repair mechanisms, accelerated apoptosis in lung cells and progression of COPD

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Targeting mitochondrial cardiolipin (SS-31 / elamipretide) PubMed

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