When to seek medical advice : Patients should contact their GP or diabetes specialist nurse if they experience: Severe, persistent vomiting preventing adequate fluid intake (risk of dehydration and acute kidney injury) Severe abdominal pain, particularly if radiating to the back (potential pancreatitisrare but serious) Right upper abdominal pain, fever, or yellowing of skin/eyes (potential gallbladder disease) Sudden vision changes (particularly with semaglutide, which may worsen diabetic retinopathy, especially with rapid HbA1c reduction) [40] [41] Signs of hypoglycaemia when used with insulin or sulphonylureas Allergic reactions (rash, difficulty breathing, facial swelling)call 999 or go to A&E for severe allergic reactions Patients should report suspected side effects via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk or the Yellow Card app)

access is limited to approved clinical trials, and no EAMS designation has been granted, so adverse events must be reported through trial pharmacovigilance processes rather than Yellow Card
At the same time, access and affordability are important public health considerations
"She's redefining what it means to be strong, once again, by setting the example that strength can also mean seeking and using medication to take control of your health
doi:10.1146/annurev-psych-010418-102936
University Hospital and University of Basel