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Neuropathic Pain: For patients with nerve-based pain, including conditions like peripheral neuropathy or chemotherapy-induced peripheral neuropathy, peptides that target nerve repair pathways show remarkable potential without the dependency risks of opioids

Published January 2008

npj Biofilms Microbiomes 11 , 11 (2025)

AMPK and other signalling pathways, such as the insulin/IGF-1 signalling (IIS), rapamycin-targeting protein (mTOR), nuclear factor-B (NF-B), and deacetylase (Sirtuins) pathways, interact with each other to form a complex network closely related to longevity and ageing [76, 100]

For example, senescent cells upregulate BCL2 family proteins such as BCL-XL, BCL-W 24 or MCL-1 25 to prevent intrinsic apoptosis

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