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Skin changes associated with weight loss may include increased skin laxity, particularly in areas where substantial fat loss occurs, such as the face, arms, abdomen, and thighs

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Constipation Occurs due to slowed gastric emptying and reduced food intake

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However, a more recent study in the journal Obesity found that a 2.4 mg dose of semaglutide still causes meaningful weight loss in people with obesity who are taking antidepressants

Speed of Weight Loss: Faster weight loss increases the likelihood and pronouncement of facial changes, as the skin has less time to adapt and retract