The more aggressive the weight loss becomes, the more important it is to focus on muscle preservation
It remains investigational and is still being studied in clinical trials, and it has not received FDA approval, so it is not yet available through a pharmacy or clinic outside of trial participation
Nystrom T, Gutniak MK, Zhang Q, Zhang F, Holst JJ, Ahrn B, Sjholm A
Severe Obesity and Established Cardiovascular Disease TRIUMPH-3 (NCT05882045) evaluated 1,949 adults with Class II or Class III obesity (body mass index of at least 35 kg/m) and established cardiovascular disease, with or without type 2 diabetes
Specific neurons in the brain stem control swallowing, intestinal movements and stress-induced loss of appetite
Eating fewer calories and increasing physical activity are also important for maintaining weight loss