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Gastrin is a neuroendocrine peptide, which acts on the cholecystokinin-2 (CCK2) receptor and is expressed in the pancreas with the rationale being that as it is involved in pancreas development, it might increase -cell mass and glycemic control [70]

The primary endpoint of weight loss of at least 5% occurred in 85% of the tirzepatide 5 mg group, 89% of the tirzepatide 10 mg group and 91% of participants in the tirzepatide 15 mg group

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