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10.1016/j.immuni.2013.10.006 216 PandeyP.KhanF.KhanM

Strategies could include dosing rapid-acting insulins 30-minutes after the start of eating (instead of the typical 15 minutes before meals), or split-bolus dosing, whereby a patient takes 50% of their rapid acting insulin before a meal, and 50% 30-minutes after the start of a meal

The findings showed increased risk of osteoporosis (relative risk 1.29), gout (relative risk 1.12), and, most strikingly, osteomalacia, which is a softening of the bones, with a relative risk of 2.55 [4]

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Tirzepatide is administered once weekly via subcutaneous injection, with doses starting at 2.5 mg for a 4-week initiation period, then titrating every 4 weeks up to a maximum of 15 mg