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Lignans are classified as diphenolic compounds and are derived from the biosynthetic pathway of shikimic acid (Hassanein et al

This is why oral doses are typically much higher than injectable equivalentsthe medication must compensate for digestive losses

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Collectively, these observations establish that NRF2 alone can sustain sufficient transcriptional output to maintain cancer cell line growth and that metabolic reprogramming of cells driven by NRF2 does not require redox buffering via enhanced glutathione production

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Proc Natl Acad Sci 73(4):13381342