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Both medications require monitoring for gallbladder changes and should not be used in patients with personal or family history of medullary thyroid cancer

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HT patients had a three times higher risk to develop papillary thyroid cancer according to some studies, while other studies did not report an increased incidence in HT patients (33)

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If this occured, it could under-report the levels of polysulfide sulfane sulfur, thus in our experiments we minimised incubation with TCEP without capping agent