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Approximately 10% to 30% of patients with steatotic liver progress to MASH, substantially increasing the risk of life-threatening complications

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Additionally, GGCT knockdown concomitantly reduced 5- oxoproline (5-OP) levels in MHCC97H cells, consistent with 5-OP being the direct enzymatic product of GGCT activity, and exogenous 5-OP rescued proliferation under Gln-deprived conditions (Fig