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After 24 weeks (~five months), people taking orlistat lost roughly 13 pounds and also reduced visceral abdominal fat a type of belly fat that accumulates deep within the abdomen by nearly 16%

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A novel glucagon-like peptide-1 (GLP-1)/glucagon hybrid peptide with triple-acting agonist activity at glucose-dependent insulinotropic polypeptide, GLP-1, and glucagon receptors and therapeutic potential in high fat-fed mice