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Orandi : Patients on dialysis are oftentimes excluded from studies like these, and so we just did not have enough data to demonstrate that GLP-1 receptor agonists were safe to use [in this population]

Researchers from the University of Toronto found that patients taking semaglutide, the active ingredient in both drugs, were twice as likely to develop neovascular age-related macular degeneration (nAMD)

The fragment bovine GIP(4-42) was a partial agonist of the rat GIP receptor, concluding that N-terminal truncation of GIP alters its pharmacological properties from full agonist to partial agonist (59)