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Peptides by definition contain amino-acid chains typically starting at ~5001,000 Da

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According to some publications, the extent and the intensity of physiological oral mucosal melanin hyperpigmentation increase with age probably owing to the cumulative effects of endogenous and extrinsic melanogenic stimuli, such as inflammatory processes, drugs, tobacco smoke, and recurrent minor functional injuries [4, 6, 11, 13]

Kunanusornchai W, Witoonpanich B, Tawonsawatruk T, Pichyangkura R, Chatsudthipong V, Muanprasat C

In the context of OA, joints constant and intense mechanical stress, high TGF- levels, and low-grade inflammation create an environment that promotes fibroblast activation and transition into myofibroblasts, as explained below

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