Suppression of glucose absorption by some fractions extracted from Gymnema sylvestre Leaves
This should only take a minute or two
Creativity thrives with constraint
It is a 31-amino acid analog of the endogenous hormone glucagon-like peptide-1 (GLP-1)
A perspective published in PLOS Medicine by Chao, Gilden, and Wadden notes that GLP-1 and dual-agonist therapies have transformed obesity care, with efficacy that rivals some bariatric procedures in selected trials as demonstrated in major Phase 3 programs while the system-level challenges of capacity, monitoring, and access remain significant
Jos Morales, MD, a vascular neurologist and neurointerventional surgeon at Providence Saint Johns Health Center in Santa Monica, CA, also not involved in this review, told MNT that microglias effect on the neurovascular unit has been associated with dementia. He suggested that: [GLP-1 drugs] could potentially modulate inflammation to reduce the propensity for developing dementias such as Alzheimers disease, particularly in the setting of metabolic syndrome. Morales also explained that in people who have glycemia or type 2 diabetes, the inflammation of the blood-brain barrier can lead to progressive damage to the brain over longer periods. He noted that trials that combine neuroimaging techniques that measure the blood-brain barrier and GLP-1 treatment are needed and could prove that these drugs have neuroprotective benefits.
