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GLP-1s may alter how your brain responds to hydration cues

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Injectable GLP-1 receptor agonists such as semaglutide, liraglutide and exenatide have transformed care, but the shift toward oral alternatives points to a wider opportunity: creating solid oral dosage forms that improve patient experience without compromising performance

Because GLP-1 cannot be deleted specifically without affecting the other products of the proglucagon gene including glucagon, attention has focused on the GLP-1 receptor gene which can be deleted independent of the glucagon receptor

Even with orally administered GLP-1 pills, roughly half of patients don't take their medications as prescribed

doi: 10.1007/s00404-015-3692-3 58 MankESenz de PipanMLapillonneACarnielliVPSenterreTShamirRet al