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Although skeletal effects are beneficial in preclinical investigations, clinical evidence on fracture risk is still uncertain

By interacting with other pathways, GPER modulates calcium channel activity and stimulates eNOS, affecting smooth muscle cell contraction and relaxation

Li X, Shi S, Jing D, et al

Tang X, Wu H, Mao X, Li X, Wang Y (2020) The GLP-1 receptor herbal agonist morroniside attenuates neuropathic pain via spinal microglial expression of IL-10 and beta-endorphin